different ballgame

Translations
совсем другое дело
Working from home is a different ballgame compared to working in an office.
Работа на дому - это совсем другое дело по сравнению с работой в офисе.
Definitions
A situation or activity that is completely different from what one is used to or has experienced before, often requiring a new approach or set of skills.
Words
different

adjective
другой
ballgame

noun
совсем другое дело